Bacterial infection can cause the body’s problems, when the patient often has weakened immune function. But complicates the problem is, given after antibiotic therapy, can reduce or prevent infection, to life in the body mainly in the gut health promoting bacteria produce negative influence. If the microflora balance is broken, can cause harmful bacteria dominated, and antibiotic resistant strains.
In view of this, scientists are more interested in, clear body is how against pathogens, but not eliminate benign bacteria. The researchers believe that to understand this point may lead to new ways to enhance the body’s natural defense against bacterial infection ability. Now researchers have identified an unusual mechanism of human body, using its mechanism can sense the presence of pathogenic bacteria and destroy them. Its mechanism is not the direct detection of microorganism, but each cell can monitor interference with mitochondrial bacteria.
Some intestinal bacteria causing mitochondrial dysfunction may contribute to infection. MSK cell biologist Cole Haynes said: as a response to the perceived some time when cells mitochondria function is disturbed, they open the promoter on bacterial attack. Haynes explained that this mechanism may have evolved to enable cells to detect harmful bacteria from the beneficial bacteria.
The Haynes team is the main research stress response, stress response is a natural mechanism of cell protection and maintenance of mitochondria. Mitochondria provide energy, allowing the cells to perform its normal function. Mitochondrial dysfunction seems to play a role in cancer and aging process. In recent years, Dr Haynes and his colleagues have focused on a protein called ATFS-1 protection. When cells are under stress, accumulation of ATFS-1 in the nucleus and the opening of a series of genes that contribute to restoring mitochondrial function. But the researchers found that ATFS-1 also opened related to fight bacterial genes. The researchers assume that maybe this stress response and innate immunity together, help the body to detect disrupted mitochondrial bacteria, and eliminate pathogens.